Pendrin localizes to the adrenal medulla and modulates catecholamine release
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چکیده
منابع مشابه
Pendrin localizes to the adrenal medulla and modulates catecholamine release.
Pendrin (Slc26a4) is a Cl(-)/HCO3 (-) exchanger expressed in renal intercalated cells and mediates renal Cl(-) absorption. With pendrin gene ablation, blood pressure and vascular volume fall, which increases plasma renin concentration. However, serum aldosterone does not significantly increase in pendrin-null mice, suggesting that pendrin regulates adrenal zona glomerulosa aldosterone productio...
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Recently, the mechanisms of storage and release of catecholamine in various tissues have become a topic of interest. The present study is on the mechanism of release of catecholamine from the adrenal medulla in an in vitro system. The adrenal medulla seems to provide a suitable system for such an in vitro study, because it contains large amounts of catecholamine in chromaffine granules, about w...
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Neuroendocrine chromaffin cells of the adrenal medulla in rat receive excitatory synaptic input through anterior and posterior divisions of the sympathetic splanchnic nerve. Upon synaptic stimulation, the adrenal medulla releases the catecholamines, epinephrine, and norepinephrine into the suprarenal vein for circulation throughout the body. Under sympathetic tone, catecholamine release is mode...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism
سال: 2015
ISSN: 0193-1849,1522-1555
DOI: 10.1152/ajpendo.00035.2015